# Home page

<h2 align="center"><strong>Welcome to the Thiamine Wiki!</strong></h2>

<h2 align="center"><em>This page is currently under construction. Make sure to check back soon!</em></h2>

***

<table data-view="cards"><thead><tr><th></th><th data-type="content-ref"></th><th></th><th data-hidden data-card-cover data-type="image">Cover image</th><th data-hidden data-card-target data-type="content-ref"></th></tr></thead><tbody><tr><td><strong>Thiamine Basics</strong></td><td><a href="/thiamine-basics/thiamine-basics/introduction-to-thiamine">Introduction to Thiamine</a></td><td></td><td><a href="https://451864704-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FDq01Tsijv7A9eV5p4M4c%2Fuploads%2FbM6CJlznGMdeJfxz5Mwg%2Fsl_040220_29550_26.jpg?alt=media&amp;token=dce251fc-9678-4e03-82a5-c6ba3d045172">sl_040220_29550_26.jpg</a></td><td><a href="/thiamine-basics/thiamine-basics/introduction-to-thiamine">Introduction to Thiamine</a></td></tr><tr><td><strong>Biochemistry</strong></td><td></td><td></td><td><a href="https://images.unsplash.com/photo-1655993810480-c15dccf9b3a0?crop=entropy&#x26;cs=srgb&#x26;fm=jpg&#x26;ixid=M3wxOTcwMjR8MHwxfHNlYXJjaHw3fHxtb2xlY3VsZXxlbnwwfHx8fDE3NjM2NzExNzR8MA&#x26;ixlib=rb-4.1.0&#x26;q=85">https://images.unsplash.com/photo-1655993810480-c15dccf9b3a0?crop=entropy&#x26;cs=srgb&#x26;fm=jpg&#x26;ixid=M3wxOTcwMjR8MHwxfHNlYXJjaHw3fHxtb2xlY3VsZXxlbnwwfHx8fDE3NjM2NzExNzR8MA&#x26;ixlib=rb-4.1.0&#x26;q=85</a></td><td></td></tr><tr><td><strong>Thiamine Deficiency</strong></td><td></td><td></td><td><a href="https://images.unsplash.com/photo-1693648793646-502abc351ae0?crop=entropy&#x26;cs=srgb&#x26;fm=jpg&#x26;ixid=M3wxOTcwMjR8MHwxfHNlYXJjaHw2fHxtb2xlY3VsZXxlbnwwfHx8fDE3NjYxMDk1ODF8MA&#x26;ixlib=rb-4.1.0&#x26;q=85">https://images.unsplash.com/photo-1693648793646-502abc351ae0?crop=entropy&#x26;cs=srgb&#x26;fm=jpg&#x26;ixid=M3wxOTcwMjR8MHwxfHNlYXJjaHw2fHxtb2xlY3VsZXxlbnwwfHx8fDE3NjYxMDk1ODF8MA&#x26;ixlib=rb-4.1.0&#x26;q=85</a></td><td></td></tr><tr><td><strong>Thiamine Supplements</strong></td><td></td><td></td><td><a href="https://images.unsplash.com/photo-1675851143055-23ae996bb212?crop=entropy&#x26;cs=srgb&#x26;fm=jpg&#x26;ixid=M3wxOTcwMjR8MHwxfHNlYXJjaHwzfHxjYXBzdWxlfGVufDB8fHx8MTc2MzY3MTIxMXww&#x26;ixlib=rb-4.1.0&#x26;q=85">https://images.unsplash.com/photo-1675851143055-23ae996bb212?crop=entropy&#x26;cs=srgb&#x26;fm=jpg&#x26;ixid=M3wxOTcwMjR8MHwxfHNlYXJjaHwzfHxjYXBzdWxlfGVufDB8fHx8MTc2MzY3MTIxMXww&#x26;ixlib=rb-4.1.0&#x26;q=85</a></td><td></td></tr><tr><td><strong>Health Conditions</strong></td><td></td><td></td><td><a href="https://images.unsplash.com/photo-1505751172876-fa1923c5c528?crop=entropy&#x26;cs=srgb&#x26;fm=jpg&#x26;ixid=M3wxOTcwMjR8MHwxfHNlYXJjaHw1fHxoZWFsdGh8ZW58MHx8fHwxNzYzNjcxNjY3fDA&#x26;ixlib=rb-4.1.0&#x26;q=85">https://images.unsplash.com/photo-1505751172876-fa1923c5c528?crop=entropy&#x26;cs=srgb&#x26;fm=jpg&#x26;ixid=M3wxOTcwMjR8MHwxfHNlYXJjaHw1fHxoZWFsdGh8ZW58MHx8fHwxNzYzNjcxNjY3fDA&#x26;ixlib=rb-4.1.0&#x26;q=85</a></td><td></td></tr><tr><td><strong>Practical Guides</strong></td><td></td><td>Choosing a supplement, adjusting the dose + more</td><td><a href="https://images.unsplash.com/photo-1635859890085-ec8cb5466806?crop=entropy&#x26;cs=srgb&#x26;fm=jpg&#x26;ixid=M3wxOTcwMjR8MHwxfHNlYXJjaHwxfHxQcm90b2NvbHxlbnwwfHx8fDE3NjM2NzE2Nzh8MA&#x26;ixlib=rb-4.1.0&#x26;q=85">https://images.unsplash.com/photo-1635859890085-ec8cb5466806?crop=entropy&#x26;cs=srgb&#x26;fm=jpg&#x26;ixid=M3wxOTcwMjR8MHwxfHNlYXJjaHwxfHxQcm90b2NvbHxlbnwwfHx8fDE3NjM2NzE2Nzh8MA&#x26;ixlib=rb-4.1.0&#x26;q=85</a></td><td></td></tr><tr><td><strong>Research Library</strong></td><td></td><td></td><td><a href="https://images.unsplash.com/photo-1667372459510-55b5e2087cd0?crop=entropy&#x26;cs=srgb&#x26;fm=jpg&#x26;ixid=M3wxOTcwMjR8MHwxfHNlYXJjaHwzfHxkYXRhYmFzZXxlbnwwfHx8fDE3NjM2NzE3Mjh8MA&#x26;ixlib=rb-4.1.0&#x26;q=85">https://images.unsplash.com/photo-1667372459510-55b5e2087cd0?crop=entropy&#x26;cs=srgb&#x26;fm=jpg&#x26;ixid=M3wxOTcwMjR8MHwxfHNlYXJjaHwzfHxkYXRhYmFzZXxlbnwwfHx8fDE3NjM2NzE3Mjh8MA&#x26;ixlib=rb-4.1.0&#x26;q=85</a></td><td></td></tr><tr><td><strong>Our Global Survey</strong> </td><td></td><td></td><td><a href="https://images.unsplash.com/photo-1504868584819-f8e8b4b6d7e3?crop=entropy&#x26;cs=srgb&#x26;fm=jpg&#x26;ixid=M3wxOTcwMjR8MHwxfHNlYXJjaHwxfHxTdXJ2ZXl8ZW58MHx8fHwxNzYzNjcxNzcwfDA&#x26;ixlib=rb-4.1.0&#x26;q=85">https://images.unsplash.com/photo-1504868584819-f8e8b4b6d7e3?crop=entropy&#x26;cs=srgb&#x26;fm=jpg&#x26;ixid=M3wxOTcwMjR8MHwxfHNlYXJjaHwxfHxTdXJ2ZXl8ZW58MHx8fHwxNzYzNjcxNzcwfDA&#x26;ixlib=rb-4.1.0&#x26;q=85</a></td><td></td></tr><tr><td><strong>Real-Life Testimonials</strong></td><td></td><td></td><td><a href="https://images.unsplash.com/photo-1511988617509-a57c8a288659?crop=entropy&#x26;cs=srgb&#x26;fm=jpg&#x26;ixid=M3wxOTcwMjR8MHwxfHNlYXJjaHw4fHxoYXBweXxlbnwwfHx8fDE3NjYxMDk2MTB8MA&#x26;ixlib=rb-4.1.0&#x26;q=85">https://images.unsplash.com/photo-1511988617509-a57c8a288659?crop=entropy&#x26;cs=srgb&#x26;fm=jpg&#x26;ixid=M3wxOTcwMjR8MHwxfHNlYXJjaHw4fHxoYXBweXxlbnwwfHx8fDE3NjYxMDk2MTB8MA&#x26;ixlib=rb-4.1.0&#x26;q=85</a></td><td></td></tr><tr><td><strong>Notable Researchers</strong></td><td></td><td></td><td><a href="https://images.unsplash.com/photo-1630959302862-82cec6653d60?crop=entropy&#x26;cs=srgb&#x26;fm=jpg&#x26;ixid=M3wxOTcwMjR8MHwxfHNlYXJjaHw0fHxSZXNlYXJjaGVyc3xlbnwwfHx8fDE3NjM2NzE2ODl8MA&#x26;ixlib=rb-4.1.0&#x26;q=85">https://images.unsplash.com/photo-1630959302862-82cec6653d60?crop=entropy&#x26;cs=srgb&#x26;fm=jpg&#x26;ixid=M3wxOTcwMjR8MHwxfHNlYXJjaHw0fHxSZXNlYXJjaGVyc3xlbnwwfHx8fDE3NjM2NzE2ODl8MA&#x26;ixlib=rb-4.1.0&#x26;q=85</a></td><td></td></tr><tr><td><strong>Glossary of Terms</strong></td><td></td><td></td><td><a href="https://images.unsplash.com/photo-1595452767427-0905ad9b036d?crop=entropy&#x26;cs=srgb&#x26;fm=jpg&#x26;ixid=M3wxOTcwMjR8MHwxfHNlYXJjaHwzfHxxdWVzdGlvbnxlbnwwfHx8fDE3NjYxMDk2Mjl8MA&#x26;ixlib=rb-4.1.0&#x26;q=85">https://images.unsplash.com/photo-1595452767427-0905ad9b036d?crop=entropy&#x26;cs=srgb&#x26;fm=jpg&#x26;ixid=M3wxOTcwMjR8MHwxfHNlYXJjaHwzfHxxdWVzdGlvbnxlbnwwfHx8fDE3NjYxMDk2Mjl8MA&#x26;ixlib=rb-4.1.0&#x26;q=85</a></td><td></td></tr></tbody></table>


# Thiamine Basics


# Introduction to Thiamine

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**This article is currently under construction**
{% endhint %}

**This wiki provides a complete overview of Thiamine (Vitamin B1)** — what it is, how it works in the body, and why it’s essential for energy, metabolism, and neurological health. Explore **simplified and detailed definitions, biochemistry, dietary sources, and factors that can affect absorption, along with the symptoms of deficiency**.


# 1. Simplified Definition of Thiamine

This article is currently under construction

**Thiamine**, also known as **vitamin B1**, is a water-soluble B-vitamin essential for converting food into energy and supporting the proper function of the nervous system, heart, and muscles. It is an indispensable nutrient that the body cannot synthesize in sufficient amounts, making dietary intake or supplementation necessary.


# Page 1


# Page 2


# 2. Relatable Overview

This article is currently under construction

Beyond energy production, thiamine acts as a key player in the nervous system, aiding in neurotransmitter synthesis and nerve signaling. It also plays a role in maintaining emotional stability and cognitive performance. Low thiamine intake or absorption issues can cause subtle symptoms at first, such as irritability and poor concentration, but if untreated, these can progress into serious neurological or cardiovascular disorders.

<br>


# 2.5 Historical Perspective

This article is currently under construction

The story of thiamine is deeply connected to one of the first recognized nutritional deficiency diseases: **beriberi**. This condition, characterized by muscle weakness, nerve degeneration, and heart failure, plagued populations in Asia during the late 19th and early 20th centuries, particularly where polished white rice was a dietary staple.

* **Discovery Timeline**:
  * **1884** – Japanese naval physician **Kanehiro Takaki** observed that supplementing sailors’ rice diet with meat and vegetables prevented beriberi, suggesting a nutritional cause.
  * **1890s** – Dutch physician **Christiaan Eijkman** demonstrated that chickens fed polished rice developed paralysis, which was reversed by adding rice husks.
  * **1910** – **Umetaro Suzuki** isolated a substance from rice bran that cured beriberi, though he could not fully characterize it.
  * **1912** – Polish biochemist **Casimir Funk** coined the term “vitamine” (vital amine) after isolating a similar factor, laying the foundation of the vitamin concept.
  * **1926–1936** – Thiamine was finally crystallized and synthesized, marking a milestone in nutritional science.

The understanding of thiamine deficiency revolutionized medicine and public health, influencing the introduction of food fortification programs worldwide.


# 3. Detailed Definition of Thiamine

This article is currently under construction

Chemically, **thiamine (C₁₂H₁₇N₄OS)** consists of two heterocyclic rings: a substituted pyrimidine and a thiazole, connected by a methylene bridge. It is a **water-soluble vitamin** and is unstable in alkaline conditions and sensitive to heat and oxidative agents.

In the body, thiamine is rapidly phosphorylated to its biologically active form, **thiamine pyrophosphate (TPP)**—also called **thiamine diphosphate (TDP)**. Other important derivatives include:

* **Thiamine monophosphate (TMP)** – An intermediate in thiamine metabolism.
* **Thiamine triphosphate (TTP)** – Found in nervous tissue; may play roles in membrane function and signal transmission.
* **Adenosine thiamine triphosphate (AThTP)** – Observed in stress responses in bacteria and mammals.


# 4. Biochemistry

This article is currently under construction


# 4.1 Role in Metabolism

This article is currently under construction

Thiamine serves as an indispensable cofactor for several enzymes that drive carbohydrate, amino acid, and lipid metabolism. Its central role is in **energy production**, particularly in oxidative decarboxylation reactions that feed into the **citric acid cycle (Krebs cycle)**, which generates ATP for cellular energy.

Without adequate thiamine, pyruvate and other intermediates accumulate, leading to lactic acidosis, impaired mitochondrial function, and neuronal energy crisis—a hallmark of thiamine-deficient states.


# 4.2 Major Coenzyme Functions

This article is currently under construction

**Thiamine pyrophosphate (TPP)** acts as a coenzyme for multiple enzyme complexes:

* **Pyruvate dehydrogenase complex (PDH)** – Converts pyruvate into acetyl-CoA, a crucial step linking glycolysis to the Krebs cycle.\
  *Real-life relevance:* When PDH is impaired, the brain—highly dependent on glucose—faces an energy shortfall, leading to confusion and neurological symptoms.
* **α-Ketoglutarate dehydrogenase (KGDH)** – Functions in the Krebs cycle, catalyzing the conversion of α-ketoglutarate to succinyl-CoA.\
  *Real-life relevance:* Essential for maintaining ATP supply in neurons; reduced activity is implicated in Alzheimer’s and Parkinson’s disease.
* **Branched-chain α-keto acid dehydrogenase (BCKDH)** – Breaks down branched-chain amino acids (valine, leucine, isoleucine).\
  *Real-life relevance:* Critical for muscle energy and recovery; deficiency affects athletes and patients with metabolic disorders.
* **Transketolase** – Key enzyme in the **pentose phosphate pathway**, facilitating ribose and NADPH production.\
  *Real-life relevance:* Supports antioxidant defense and DNA synthesis; compromised activity increases oxidative stress in the brain.
* **2-Hydroxyacyl-CoA lyase 1 (HACL1)** – Participates in **peroxisomal α-oxidation** of fatty acids.\
  *Real-life relevance:* Important for lipid metabolism in neural tissue.
* **2-Oxoadipate dehydrogenase (OADH)** – Involved in degradation of lysine and tryptophan.\
  *Real-life relevance:* Affects neurotransmitter balance and mitochondrial health.


# 4.3 Non-Coenzyme Functions

This article is currently under construction

Beyond its coenzyme roles, thiamine and its derivatives contribute to:

* **Signal modulation** – Influencing ion channels and synaptic transmission.
* **Oxidative stress protection** – Acting as an antioxidant and enhancing glutathione status.
* **Neurotransmitter synthesis** – Supporting acetylcholine and GABA pathways, influencing cognition and mood.
* **Membrane function** – Thiamine triphosphate may regulate chloride channels in neurons.


# 4.4 Clinical Implications of Dysfunction

This article is currently under construction

Defective thiamine-dependent enzymes or impaired thiamine status are linked to:

* **Neurodegenerative diseases** – Reduced transketolase activity and mitochondrial dysfunction in Alzheimer’s, Parkinson’s.
* **Diabetes complications** – Thiamine loss in urine contributes to neuropathy.
* **Cardiac failure** – Wet beriberi mimics heart failure syndromes.
* **Genetic disorders** – Mutations in thiamine transporter genes (e.g., SLC19A2) cause thiamine-responsive megaloblastic anemia.


# 5. Dietary Sources

This article is currently under construction

Major sources of thiamine include:

* Whole grains and enriched cereals
* Pork and organ meats
* Legumes (beans, lentils)
* Seeds and nuts
* Brewer’s yeast

**Stability note:** Thiamine is heat-sensitive and easily lost during boiling or prolonged cooking. Milling and refining grains remove the thiamine-rich outer layers, which is why fortification programs exist.

Absorption occurs primarily in the **jejunum** through active transport at physiological levels, shifting to passive diffusion at pharmacological doses.


# 6. Anti-Nutrient Factors

Factors that impair thiamine availability include:

* **Thiaminases** – Enzymes in raw freshwater fish and ferns that break down thiamine.
* **Alcohol** – Reduces absorption and impairs phosphorylation into active forms.
* **Polyphenols** – Tea and coffee compounds form complexes with thiamine.
* **Heat and pH** – Cooking and alkaline conditions destroy thiamine.


# 7. Deficiency

This article is currently under construction

Thiamine deficiency is often overlooked in modern medicine, yet it persists in alcoholism, malabsorption syndromes, chronic illness, and high-carbohydrate diets.

### **Progression:**

* **Early signs:** Fatigue, irritability, poor concentration, mild neuropathy.
* **Moderate deficiency:** Muscle weakness, anorexia, gastrointestinal discomfort, mood changes.
* **Severe deficiency syndromes:**
  * **Dry beriberi:** Peripheral neuropathy, muscle wasting, foot drop.
  * **Wet beriberi:** Cardiac enlargement, tachycardia, heart failure with edema.
  * **Wernicke’s encephalopathy:** Confusion, ataxia, ophthalmoplegia; can progress to coma.
  * **Korsakoff’s psychosis:** Chronic amnesia and confabulation due to permanent brain damage.

**Mechanistic basis:** Energy failure in neurons and cardiomyocytes, lactic acidosis, and increased oxidative stress are central to thiamine deficiency pathology.


# Established Thiamine Deficiency Disorders


# Dry (Neurological) Beriberi


# Wet (Cardiovascular) Beriberi


# Wernicke Encephalopathy


# Korsakoff Syndrome


# Gastrointestinal Beriberi


# Health Conditions Associated with Thiamine Deficiency


# Symptoms Associated with Deficiency


# Genetics


# Page 4


# Causes of Thiamine Deficiency


# Page 3


# Risk Factors


# Prevalence


# Thiamine Biochemistry Overview


# Thiamine Transport


# Thiamine Transporter 1 (SLC19A2)


# Thiamine Transporter 2 (SLC19A3)


# Thiamine Pyrophosphate Transporter (SLC44A4)


# Organic Cation Transporter (OCT)


# Reduced Folate Carrier (RFC)


# Thiamine Derivatives


# Thiamine


# Thiamine Diphosphate (Pyrophosphate)


# Thiamine Monophosphate


# Thiamine Triphosphate


# Adenosine Thiamine Triphosphate


# Thiamine-Dependent Enzymes


# Pyruvate Dehydrogenase


# Alpha-Ketoglutarate Dehydrogenase


# Oxoadipate Dehydrogenase


# Hydroxyacyl CoA Lyase


# Transketolase


# Non-Coenzyme Effects


# Allosteric Regulation of Other Enzymes


# Acetylcholine Signalling


# Metabolism


# Antioxidant System


# Central Nervous System (Brain & Spine)


# Skin


# Peripheral Nerves


# Gastrointestinal System


# Cardiovascular System (Heart & Blood Vessels)


# Muscles & Fat


# Endocrine (Hormonal)


# Thiamine Supplements


# Thiamine Salts


# Thiamine Hydrochloride


# Thiamine Mononitrate


# Thiamine Pyrophosphate


# Disulfide Thiamine Derivatives


# Thiamine Tetrahydrofurfuryl Disulfide (TTFD)


# Sulbutiamine


# Prosultiamine


# Benzoyl Derivatives


# Benfotiamine


# Dibenzoyl Thiamine (DBT)


# Overview of Thiamine's Therapeutic Effects


# Practical Guides Overview


# Adjusting Dosage


# What is a "High Dose"?


# Page 5


# What is an "Effective Dose"?


# Overview


# Dr. Derrick Lonsdale


# Dr. Victoria Bunik


# Dr. Lucien Bettendorff


# Dr. Gary Gibson


# Real-World Thiamine Outcomes Survey

This project collects **real-world experiences** of people using thiamine to support their health. The goal is to build an open, searchable resource showing which forms and doses of thiamine seem most useful for different symptoms and conditions.

The data will periodically be analyzed and presented here. Testimonials will be categorized and searchable.&#x20;

### What are we hoping to learn about?

<table data-view="cards"><thead><tr><th></th><th></th><th></th><th data-hidden data-card-cover data-type="files"></th><th data-hidden></th><th data-hidden data-card-target data-type="content-ref"></th></tr></thead><tbody><tr><td><h4><i class="fa-rectangle-history-circle-plus">:rectangle-history-circle-plus:</i></h4></td><td><strong>Type of health condition</strong></td><td>Which conditions respond to thiamine?</td><td></td><td></td><td><a href="/real-world-survery-results/broad-overview/quickstart">Overview of the results</a></td></tr><tr><td><h4><i class="fa-prescription-bottle-medical">:prescription-bottle-medical:</i></h4></td><td><strong>Form of thiamine supplement</strong></td><td>Which form helps the most? </td><td></td><td></td><td><a href="https://github.com/GitbookIO/gitbook-templates/blob/main/product-docs/broken-reference/README.md">https://github.com/GitbookIO/gitbook-templates/blob/main/product-docs/broken-reference/README.md</a></td></tr><tr><td><h4><i class="fa-gauge-simple-high">:gauge-simple-high:</i></h4></td><td><strong>The optimal dosage</strong></td><td>Which dosage is the most effective?</td><td></td><td></td><td><a href="broken://pages/QPzbTvC6XsT5gERiU43E">Broken link</a></td></tr><tr><td><i class="fa-timer">:timer:</i></td><td><strong>Recovery timeline</strong></td><td>How long does it typically take for people to see improvements?</td><td></td><td></td><td></td></tr><tr><td><i class="fa-face-sad-tear">:face-sad-tear:</i></td><td><strong>Paradoxical effects</strong></td><td>Do people experience adverse reactions, and for how long to does last?</td><td></td><td></td><td></td></tr><tr><td><i class="fa-question">:question:</i></td><td><strong>Other variables</strong></td><td>Are there any other important variables which influence responsiveness to thiamine?</td><td></td><td></td><td></td></tr></tbody></table>


# Overview of the results


# Type of health condition


# Form of thiamine supplement


# The optimal dose


# Recovery timeline

In addition to the default Markdown you can write, GitBook has a number of out-of-the-box interactive blocks you can use. You can find interactive blocks by pressing `/` from within the editor.


# Paradoxical effects (adverse reactions)


# Other factors


# Developer Platform

Welcome to your team’s developer platform

<h2 align="center">Thiamine Testimonial Database</h2>

This project collects **real-world experiences** of people using thiamine to support their health. The goal is to build an open, searchable resource showing which forms and doses of thiamine seem most useful for different symptoms and conditions.

Anonymized testimonials will be categorized and searchable. You can search by **type of health condition** or by **form of thiamine supplement** used.&#x20;

<table data-view="cards"><thead><tr><th></th><th></th><th></th><th data-hidden data-card-target data-type="content-ref"></th><th data-hidden data-card-cover data-type="files"></th></tr></thead><tbody><tr><td><h4><i class="fa-leaf">:leaf:</i></h4></td><td><strong>No code</strong></td><td>Get started with the developer platform in 5 minutes.</td><td><a href="https://template.gitbook.com/space-product-docs">https://template.gitbook.com/space-product-docs</a></td><td><a href="https://content.gitbook.com/content/N8h9YVZOEJLmOWtUX5yK/blobs/mZz2erRG9qfJHxwpVCWY/no-code.jpg">no-code.jpg</a></td></tr><tr><td><h4><i class="fa-server">:server:</i></h4></td><td><strong>Hosted</strong></td><td>Learn more about hosting the developer platform.</td><td><a href="https://template.gitbook.com/space-product-docs">https://template.gitbook.com/space-product-docs</a></td><td><a href="https://content.gitbook.com/content/N8h9YVZOEJLmOWtUX5yK/blobs/bh3fDMUtsvoM0zex6D12/hosted.jpg">hosted.jpg</a></td></tr><tr><td><h4><i class="fa-terminal">:terminal:</i></h4></td><td><strong>API reference</strong></td><td>Browse, test, and implement APIs.</td><td><a href="https://template.gitbook.com/space-api-reference">https://template.gitbook.com/space-api-reference</a></td><td><a href="https://content.gitbook.com/content/N8h9YVZOEJLmOWtUX5yK/blobs/bDe3pvIt79zns8rL6sOn/api-reference.jpg">api-reference.jpg</a></td></tr></tbody></table>

{% columns %}
{% column %}

### Get started in 5 minutes

Setting up your first API call should be the easiest part of getting started. With clear endpoints, copy-paste-ready examples, and quick authentication, you’ll be up and running in minutes—not hours.

No guesswork, no complexity—just your first successful call, fast.

<a href="https://template.gitbook.com/space-product-docs" class="button primary" data-icon="rocket-launch">Get started</a> <a href="https://template.gitbook.com/space-api-reference" class="button secondary" data-icon="terminal">API reference</a>
{% endcolumn %}

{% column %}
{% code title="index.js" overflow="wrap" %}

```javascript
// Import the SDK
import ExampleAPI from "example-api";

// Initialize the client
const client = new ExampleAPI({ apiKey: "YOUR_API_KEY" });

// Send your first message
const response = await client.messages.send({
  message: "Hello, world!"
});

```

{% endcode %}
{% endcolumn %}
{% endcolumns %}

{% columns %}
{% column %}

<figure><img src="https://gitbookio.github.io/onboarding-template-images/placeholder.png" alt=""><figcaption></figcaption></figure>
{% endcolumn %}

{% column %}

### Learn more about the developer platform

Read guides, watch tutorials, and learn more about working with the developer platform and integrating it with your own stack.

<a href="https://template.gitbook.com/space-help-center" class="button primary" data-icon="book-open">Guides</a> <a href="https://template.gitbook.com/space-product-docs" class="button secondary" data-icon="book">Documentation</a>
{% endcolumn %}
{% endcolumns %}


# Share your story

Support this project by sharing your story. It only take a few minutes!

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